CONTEMPORARY UPDATE OF PROSTATE CANCER STAGING NOMOGRAMS (PARTIN TABLES) FOR THE NEW MILLENNIUM Alan W Partin*, Patrick C Walsh, Jonathan I Epstein. Baltimore. MD; Jay D Pearson. Rahway. NJ

Introduction and Objectives: We previously presented nomograms combining pre-operative serum tPSA clinical (TNM) stage, and biopsy Gleason Score to provide the likelihood of various final pathological stages at radical prostatectomy (RRP) (Partin et al. JAMA 277: 1445, 1997). Data for the original nomograms were collected from men treated between 1982 and 1996. Over the past five years, stage at presentation has shifted with more men presenting with stage T1c, Gleason score 5-6 and serum PSA levels less than 10.0 ng/ml. In this work we update the "Partin Tables" with a more contemporary cohort of men treated since 1994 with revised PSA and Gleason categories.

Methods: Multinomial log-linear regression was used to estimate the likelihood of organ confined, capsular penetration, seminal vesicle or lymph nodal status on pre-operative PSA stratified as (<2.5, 2.5-4.0., 4.1-6.0, 6.1-10.0, >10), Clinical (TNM) stage (T1c, T2a, T2b, or T2c) and biopsy Gleason score stratified as (2-4, 5-6, 3+4=7, 4+3=7 or 8-10) among 5,079 men treated with RRP (without neoadjuvant therapy) between 1994 and 2000 at The Johns Hopkins Hospital. Average age was 58 years.

Results: In this cohort, >60% were T1c, >75% were Gleason score 6, >70% had a PSA >2.5 and <10.0 ng/ml, and >60% had organ-confined disease. Nomograms of the robust estimated likelihoods and 95% confidence intervals were developed from 1000 bootstrap analyses. The improved outlook for this contemporary cohort will be highlighted.