Prostatic intraepithelial neoplasia in surgical resections: relationship to coexistent adenocarcinoma and atypical
adenomatous hyperplasia of the prostate.

Skjorten FJ, Berner A, Harvei S, Robsahm TE and Tretli S.
Cancer 1997, 79: 1172-1179.

This study looked at the presence of prostatic intraepithelial neoplasia (PIN) in 1,135 consecutive surgical
resections. High grade PIN was found more commonly in samples from patients with small tumours. The
inter-observer agreement (chance-corrected proportional-agreement) was 0.66 for PIN and 0.89 for carcinoma;
the latter may seem low. No association was found between atypical adenomatous hyperplasia and prostate
cancer, but data from the follow-up of patients was not included in the analysis.